Testosterone replacement therapy for late-onset hypogonadism syndrome with mental disorder Masaki Kimura 1 , Kenichi Sasaki 1 , Kaori Endo 1 , Atsushi Kanatani 1 , Yukio Yamada 1 , Hideyo Miyazaki 1 , Tohru Nakagawa 1 Keyword: 精神疾患 , LOH症候群 , テストステロン補充療法 pp.1019-1025
Published Date 2018/11/20
DOI https://doi.org/10.11477/mf.1413206431
  • Abstract
  • Look Inside
  • Reference


A variety of psychological problems will occur in men with late-onset hypogonadism (LOH) syndrome, which is caused by decreased serum testosterone level. However, little is known about the efficacy of testosterone replacement therapy (TRT) for men with LOH syndrome who have mental disorder. We investigated a total of 201 men with LOH syndrome who underwent TRT. Among 201 men, 70 men had mental disorder, such as depression, generalized anxiety disorder, and schizophrenia. It was observed that LOH patients who had mental disorder were more likely to be younger with higher aging male symptoms score, whereas there was no difference in free testosterone level before TRT. Regardless of mental disorder, efficacy and treatment pattern of TRT were not significantly different between groups. Especially, among men who had depression and anxiety disorder, it seems that TRT relieved those psychological symptoms. Therefore, own present results demonstrated that TRT could be a feasible option for men with mental disorder (Rinsho Hinyokika 72 : 1019-1025, 2018).

Copyright © 2018, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1332 印刷版ISSN 0385-2393 医学書院