外傷性・術後皮膚潰瘍に対し有効であったbasic fibroblast growth factor（bFGF），prostaglandin E1（PGE1）製剤併用療法の小経験

Treatment of Traumatic and Postoperative Skin Ulcers Using bFGF and PGE1

　外傷性・術後皮膚潰瘍に対し，bFGF，PGE₁製剤併用療法が有用であったので報告する．対象は外傷が4例，術後潰瘍が2例，計6例で，bFGF製剤を創面に散布後PGE₁製剤を十分に塗布し，創面が湿潤状態を保つように被覆した．本療法開始後，外傷が平均8.3日，術後潰瘍が平均41日で良好な肉芽形成，上皮化が得られた．bFGF製剤は強力な血管新生作用，肉芽形成促進作用を持ち，PGE₁製剤は血管拡張作用，血小板凝集作用を持つ．本療法は，外傷性・術後皮膚潰瘍の治癒期間を短縮する可能性があると考えられた．

　We report six cases of skin ulcers that were treated with bFGF and PGE₁. Four of the cases, were traumatic ulcers, and two of the cases were postoperative ulcers. After spraying the ulcers with bFGF, a PGE₁ ointment was amply applied and the wounds were covered with a wet dressing. Granulation and epithelialization appeared after a mean of 8.3 days for the traumatic ulcers, and 41 days for the postoperative ulcers. bFGF spray strongly promotes granulation and vasculation, while PGE₁ ointment promotes peripheral vasodilatation and anti-platelet mechanisms. This combined treatment is thus effective for traumatic and postoperative skin ulcers.