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骨原発悪性リンパ腫(PLB)9例(男性3例,女性6例,平均年齢64歳)について検討を行った.平均経過観察期間は19カ月であった.臨床病期はIE期が6例,IV期が3例であった.病理組織型は全例びまん性B細胞性大細胞型であった.治療は,化学療法が全例に,放射線療法(30~40Gy)が7例に行われた.8例で浸潤性骨破壊を示し,骨外腫瘤が認められた.治療後,6例(66.7%)で完全寛解が得られた.5年累積生存率は58.3%であった.PLBの治療成績は化学療法と放射線療法により,比較的良好である.
We reviewed the cases of 9 patients―3 men and 6 women with a mean age of 64 years―with primary lymphoma of the bone (PLB). Mean follow-up was 19months. Six patients were classified as stage IE and 3 as stage IV. All had diffuse large B-cell histology. All were treated with chemotherapy, with 7 undergoing field radiotherapy (30-40 Gy). Eight of 9 showed permeative osteolytic lesion and extraskeletal soft tissue involvement. After therapy, 6 of the 9 (66.7%) reached CR. Overall survival at 5 years was 58.3%. Patients with PLB thus have a favorable outcome with chemotherapy and involved field radiotherapy.
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