25歳発症，パーキンソニズムを呈し，18年の経過で死亡した43歳女性

A 43-year-old Woman with 18 Years History of Parkinsonism

症例呈示

　症例　K．M．，43歳女性，右利き。

　家族歴　4人兄弟の4番目，神経疾患（—）。

We report a 43-year-old woman who died after 18 years history of parkinsonism. She was well until 25 years of the age (1976) when she noted a difficulty in stepping her feet. In the next year, she started to drag her feet. She was treated with levodopa withgood response, however, she developed dyskinesia when she was 33 years of the age. She was evaluated in another hospital in 1984. She showed normal intelligence, normal ocular movement, masked face, small voice, small step gait, stooped posture, freez-ing of the gait, retropulsion, and cogwheel rigidity in limbs.