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A STUDY ON THE NON-INFLAMMATORY LESIONS OF NEUROSYCHILIS.:Report I. An Autopsy Case of Tabes Dorsalis Combined with Status Dysraphicus and Alzheimer's Fibrillary Change in Ammon's Horn Tatsunori MATSUOKA 1 , Koho MIYOSHI 1 , Keiichi SAKA 1 , Tomokatsu KAWAGOE 1 , Goro NAKAMURA 2 1Dept. of Neuropsychiatry, Kyoto Univ., Medical School pp.27-32
Published Date 1968/1/1
DOI https://doi.org/10.11477/mf.1406202331
  • Abstract
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History : A 55-year-old woman was admitted to the Rakunan Mental Hospital in Kyoto on May, 1964, because of a 18-years' history of progressive illness characterized by hypesthesia of limbs and progressive dementia. Preceedingly she had sychilis at the age of 27 and received an incomplete an-tiluetic cure. On admission, blood Wassermann reac-tion was negative, and a spinal tap revealed normal. In spite of intensive antiluetic therapy the symptoms were not improved. From June 1965 on, she started having total incontinence, and in December she lapsed into astasia and abasia because of tottering hypotonia on the joints of limbs. She expired on December 22nd after 2 days' duration of camatose state.

Post mortem findings : The brain weighed 1070 gramms, and mild atrophy of bilateral frontal lobes was revealed on gross inspection. The posterior column of the spinal cord was gelatinous and brow-nish-tinged on transeverse sections.

Histologically : Alzheimer's fibrillary change in hippocampus was the only remarkable change found in the brain, although the mild astrocytic prolifera-tion and neuronophagy were disseminated through-out the cerebral cortex. In the spinal cord the typical findings of "lumber tabes" were observed. In addi-tion to these the status dysraphicus was found at thelower thoracic level.

Comments : Pathogenesis of tabes dorsalis as well as the significance of status dysraphicus were shortly discussed. The possibility of remedial disappearance of cortical changes in case of tabo-paralysis was considered, and Alzheimer's fibrillary changes was explained with the synaeretic mechanism in spheres of inflammation.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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