統合失調症の多飲症に対してquetiapineが奏効した2症例

Two Case Reports of Schizophrenia with Polydipsia Successfully Treated with Quetiapine

抄録

　精神科病院に長期入院の患者の多飲症はしばしば認められる。しかし，多飲症は飲水制限以外に有効な治療法がなく，長期にわたる隔離や身体的拘束を要することもあり，治療に難渋することが多い。今回，多飲症が遷延した統合失調症患者にquetiapineを投与することにより改善した2症例を経験した。非定型抗精神病薬による多飲症の改善に関する報告は少なく，quetiapineの多飲症治療における有用性に関し，若干の考察を加えて報告する。

　Polydipsia is a potentially fatal condition observed in patients with chronic psychiatric illness, especially schizophrenia. In general, management of this condition is difficult, as patients are uncooperative and secretive about their water intake, but important in terms of the associated complications. Several strategies, including involuntary fluid restriction and isolation or restriction have been used for the treatment of this condition with inconsistent results. Antipsychotics have also been used in the treatment of polydipsia. However, their role remains to be delineated. Herein we present two schizophrenia cases with polydipsia that were successfully treated with quetiapine. This report suggests the possible effectiveness of quetiapine for polydipsia in schizophrenics.