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The Efficacv of Nisoldipine on Myocardiai Perfusion in patients with Silent Myocardial Ischemia Junichi Yamazaki 1 , Hiroshi Muto 1 , Katsutoshi Naitou 1 , Shuichi Ishida 1 , Nariaki Uno 1 , Kenichirou Saisho 1 , Takehiko Munakata 1 , Chie Suganami 1 , Fukunori Hattori 1 , Yuko Togane 1 , Takeshi Morishita 1 1First Department of Internal Medicine, Toho University School of Medicine Keyword: 201T1心筋SPECT , 無症候性心筋虚血 , ニソルジピン , 201Tl myocardial SPECT , silent myocardial ischemia , nisoldipine pp.595-600
Published Date 1997/6/15
DOI https://doi.org/10.11477/mf.1404901498
  • Abstract
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Patients who had old myocardial infarction associat-ed with myocardial viability and ischemia were divided into a pain-free group and a pain positive group of nine patients each. The improvement of myocardial per-fusion with nisoldipine therapy was compared between the two groups using exercise load Tl 201 myocardial SPECT (myocardial SPECT). The exercise time was significantly prolonged from 505 seconds to 607 seconds after administration of nisoldipine in the pain-positive group (p<0.05). but there was no change in the pain free group. The extent score of the full circumference of the left ventricle, the severity score. and the %Tl uptake of the infarcted region were significantly improved in both groups by administration of nisoldipine. These findings suggested that nisoldipine caused a decrease in the myocardial oxygen requirements associated with reduction of the afterload and coronary artery dilata-tion in the pain- positive group, but mainly caused coro-nary dilatation in the pain-free group. Since myocardial perfusion also improved after nisoldipine administration in the pain-free group, the possibility that calcium antagonists can be used for prophylactic treatment of asymptomatic myocardial ischemia was suggested.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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