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Two Cases of Second-degree Atrioventricular Block Associated with Interferon Therapy for Chronic Hepatitis C Toru Kubota 1 , Shunichi Kaseda 1 , Megumu Yoshida 1 , Toshihiko Kubo 1 , Shiomi Aimitsu 2 , Yoshihiro Ikemoto 2 , Hiroshi Kouno 2 1Department of Cardiology, Hiroshima Red-Cross and Atomic Bomb Survivors Hospital 2Department of Internal Medicine, Hiroshima Red-Cross and Atomic Bomb Survivors Hospital Keyword: C型慢性肝炎 , インターフェロン , 房室ブロック , chronic hepatitis C , interferon , atrioventricular block pp.983-987
Published Date 1994/10/15
DOI https://doi.org/10.11477/mf.1404900941
  • Abstract
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We report here two cases of second-degree atrioventricular block (AVB) that occurred during interferon (IFN) therapy for chronic hepatitis C. Case 1 was a 34 year-old man. Two weeks after starting IFN α-2b, the PQ interval was prolonged from 220 msec to 580 msec without visible effects. The ambulatory elec-trocardiogram revealed Wenckebach AVB. We stopped administrating IFN α-2b after 20 weeks (i. e., 420×106 units in total). However, the second-degree AVB was still continuing. Case 2 was a 54-year-old woman. Two months after starting IFN α-2a, shebegan to complain of chest discomfort at rest.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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