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Pathological Features of Oro−Laryngo−Pharyngeal Cancer Tetsuo Nemoto 1 , Junko Aida 1 , Mutsuko Omatsu 1 , Chihiro Koike 1 , Yasuhiro Nihon-yanagi 1 , Yumi Asai 1 , Hitomi Kera 1 , Jun Ohara 2 , Yuta Kouyama 3 , Arisa Yasuda 4 , Naobumi Tochigi 5 1Department of Diagnostic Pathology and Laboratory Medicine, Showa University Northern Yokohama Hospital, Yokohama, Japan 2Department of Pathology, Showa University School of Medicine, Tokyo 3Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan 4Department of Dentistry and Oral Surgery, Showa University Northern Yokohama Hospital, Yokohama, Japan 5Department of Surgical Pathology, Toho University Medical Center Omori Hospital, Tokyo Keyword: 口腔 , 咽喉頭 , 病理組織 , EBウイルス , ヒトパピローマウイルス , 上皮下層 pp.1101-1111
Published Date 2023/9/25
DOI https://doi.org/10.11477/mf.1403203314
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 The oral mucosa is covered with keratinized and nonkeratinized squamous epithelium, giving rise to squamous cell carcinoma, and its incidence is highest in the tongue, followed by the gingiva, oral floor, buccal mucosa, and the palate. In contrast, the incidence of esophageal cancer is high in the buccal and oral floor mucosae. The pharynx comprises the upper pharynx, middle pharynx, and hypopharynx and is covered with nonkeratinized squamous epithelium. The upper pharynx and middle pharynx consist of the lymphoid apparatus of the tonsils. Most of the laryngeal mucosa is covered with ciliated epithelium, but a part of the epiglottis and vocal folds are covered with squamous epithelium. Squamous cell carcinoma is the most commonly occurring malignant tumor in all the regions. Nasopharyngeal carcinoma develops in the nasopharynx with dense lymphocytic infiltration and is usually accompanied by the Epstein−Barr virus infection. Oropharyngeal cancer has different characteristics, including prognosis, between human papilloma virus-positive and negative cancers, and the requirement of p16 immunostaining for pathological diagnosis. However, the morphologies of squamous cell carcinoma of the hypopharynx and esophagus, including the tumor vascular pattern detected using magnifying endoscopy are similar. Unlike the esophagus, there is no muscularis mucosae in the hypopharynx. Thus, the connective tissue immediately below the epithelium should be termed the “subepithelial layer” instead of the submucosal layer.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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