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Localized Sarcoidosis in the Esophagus, Report of a Case Yusato Suzuki 1 , Tamotsu Matsuhashi 1 , Mario Jin 1 , Reina Oba 1 , Hisashi Shiga 1 , Natsumi Hatakeyama 1 , Shigeto Koizumi 1 , Kengo Onochi 1 , Masayuki Sawaguchi 1 , Yosuke Simodaira 1 , Yusuke Sato 2 , Satoru Motoyama 2 , Hiroshi Nanjyo 3 , Katsunori Iijima 1 1Department of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan 2Department of Thoratic Surgery, Akita University Graduate School of Medicine, Akita, Japan 3Division of Clinical Pathology, Akita University Hospital, Akita, Japan Keyword: サルコイドーシス , 食道 , 粘膜下腫瘍 , 非乾酪性類上皮細胞肉芽腫 , Langhans型巨細胞 pp.1467-1472
Published Date 2016/10/25
DOI https://doi.org/10.11477/mf.1403200751
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 A 76-year-old man with severe progressive dysphagia was previously diagnosed with a submucosal tumor and was referred to our hospital for further examination and treatment because biopsy specimens revealed non-specific inflammation. Endoscopic examination at our hospital revealed constriction of the entire circumference of the esophagus measuring 6cm in diameter and located 27cm distal to the incisors. The constricted region was not covered with non-neoplastic epithelium. Positron emission tomography─computer tomography further revealed irregular thickening of the upper to middle esophagus, whereas radiolabeled[18F]-2-fluoro-2-deoxy-D-glucose uptake demonstrated significant accumulation in the bilateral hilar areas(maximum standardized uptake value was 14.6). Pathological findings from an open biopsy were unable to confirm sarcoidosis resulting from the malignant disease. For definitive diagnosis and treatment, we performed radical esophagectomy. Histopathological findings revealed epithelioid cell granulomas with multiple Langhans giant cells without caseation and were thus compatible with sarcoidosis.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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