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Ménétrier's Disease (located giant hypertrophy of the gastric mucosa with diffuse polyposis) Associated with Polyposis of the Colon, a Case Report K. Nagano 1 , H. Sano 1 , S. Tahara 2 , Y. Yasuda 2 , Y. Moriyama 2 , M. Takahashi 3 1Dept. of Int. Med., Hakodate Kyoaikai Hospital 2Dept. of Surgery, Hakodate Kyoaikai Hospital 3Dept. of Pathology, Kyorin University pp.1475-1482
Published Date 1973/11/25
DOI https://doi.org/10.11477/mf.1403108448
  • Abstract
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 Giant hypertrophy of the gastric mucosa with diffuse polyposis, coexistence of themselves were very rarely, associated with polyposis of the colon, was recently encountered and surgically treated. Surprisingly seldom has been the description of lesions of the lower digestive canal in literature of the Ménétrier's disease up to now, some reference has also been made both to this problem points and to its literature in general.

 The patient, a man 48 years of age, was seen first on September 1972 because of unpleasant sensation around the navel directly after meals and he was admitted to the author's hospital for thorough examination. Except for slight tenderness around the appendectomical scar and in the lower right quadrant, physical examination was non-contributory. No pigmentation, no edema and no nail or bone dystrophy was recognized. Gastrointestinal series disclosed irregular, tortuous, highly-thickened mucosal rugae at the corpus and numerous sessile small polypoid lesions in the pyloric antrum, which also extend into the angular region of lesser curvature and the cardia. Barium enema study showed many flat small polypoid defects, especially in the rectum and sigmoid. Gastrofibrescopic study revealed numerous polypoid lesions, which were belonged to type Ⅰ or Ⅱ type as designed by Yamada and noted no reddness or depression on their surfaces, in the pyloric antrum, angular region and cardia, and coarse tortuous giant folds looked like cerebral convolutions. Hypersecretion of gastric mucus was noticed. Colonofibrescopic study revealed also numerous sessile polypoid lesions in the rectum and sigmoid. These surface were same as surrounding colonal mucosa. Biopsy specimens taken from polyposis and giant folds of the stomach and polyposis of the colon disclosed Group type Ⅰ. Gastric juice showed normal acidity and plasma protein level was 6.8 g/dl with normal protein fraction. Intravenous RISA test and 51Cr labeled human serum albumin disapperance test were perfectly normal. These findings led the author to the diagnosis of the Ménétrier's disease (Polyadénomes en nappe et polypeux) associated with polyposis of the colon and total gastrectomy (with esophagojejunostomia) was performed. The resected stomach was large, highly-thickened, looked like a bag of worms. Essentially, giant folds of the gastric mucosa at the same histological findings as diffuse polyposis were based on the hypertrophy of the gastric glands and were belonged to B group of Nakamura's classification, noticed few findings of the atrophic hyperplastic gastritis.


Copyright © 1973, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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