Stomach and Intestine(Tokyo) Volume 14, Issue 6 (June 1979)

Difference of Colonic Mucosa as Backgrounds of Single Advanced Carcinoma, Benign Diseases and Familial Polyposis of the Colon T. Oohara 1 , A. Ogino 1 , K. Saji 1 , H. Tohma 2 1The 3rd Dept. of Surgery, School of Medicine, Tokyo University 2Tohma Hospital pp.811-818
Published Date 1979/6/25
  • Abstract
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 The fact that there are numerous adenomas in the colonic mucosa bearing familial colonic polyposis is one of the important base for the theory of adenoma-carcinoma sequence in the colon. On the other hand, it seems that there are comparatively too little incidence of coexisting adenomas of the colon bearing ordinary single carcinoma. The purpose of this paper is to report our histological study of the colonic mucosa as backgrounds of various diseases of the colon.

 The material consisted of 17 cases of single advanced carcinoma (cancer group), 4 cases of benign lesions (benign group), and 4 cases of familial colonic polyposis (polyposis group). Fixed specimens of the colon in these 25 cases were stepsectioned perpendicularly to the long axis with each slice being about 7 mm.

 (1) The changes of the basal cell layer: Glandular tubules at the basal cell layer, a proliferative zone, were found densely packed with rather a small number of goblet cells in the cancer group. On the contrary, clear and loose with completely differentiated goblet cells in the polyposis group. The findings in the benign group were similar to those in the cancer group.

 (2) Buds of adenoma: Minute adenomas (bud of adenoma), which were macroscopically unrecognizable, were found by 16 lesions in 8 cases of the cancer group, 1 lesion in a case of the benign group and numerous in all cases of the polyposis group. All of them developed from the basal cell layer.

 These findings indicate that the colonic mucosa of the cancer group and benign group is similar to each other, but is different from that of the polyposis group, and that adenomas particularly minute buds which have not been cited in the past are not uncommon in the non-polyposis groups.

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14巻6号 (1979年6月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院