Genetic Changes in Development of Gastric Carcinoma Yo Kato 1 , Kenji Aizu 1 , Akio Yanagisawa 1 1Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Keyword: 胃癌 , 組織型 , 遺伝子変化 , 発生・進展 pp.77-82
Published Date 1995/1/25
DOI https://doi.org/10.11477/mf.1403105295
  • Abstract
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 The still rapidly expanding knowledge of genetic changes in gastric carcinogenesis was summarized. When gastric carcinomas are divided into differentiated type (DCA) and undifferentiated type (UCA), amplification of c-met gene, and mutations of APC gene (well or moderately differentiated adenocarcinoma and signet-ring cell carcinoma) and p53 gene are changes common to both types. Specifics for DCA are mutation of ras gene (though rare), amplification of c-erbB-2 gene and loss of heterozygosity (LOH) of c-met gene. On the other hand for UCA, amplification of K-sam, and replication error (RER) in microsatellite marker DNAs is supposed to reflect genetic instability (poorly differentiated carcinoma). LOHs on several chromosomal arms were also referred to. In so-called ATP or flat adenoma, mutation of APC gene is frequent compared to other genetic alterations. It is suggested that it is useful to examine RER in microsatellite marker DNAs from the tumor for the screening of patients at risk of developing of multiple cancer.

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