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Mucinous Phenotype and Activity of Cell Proliferation in the Linitis-type of Gastric Cancer Cell Katsuo Morita 1 , Takahiro Fujimori 1 1Department of Pathology, Dokkyo University School of Medicine Keyword: TGF-β , TGF-βRII , linitis型 , “pre-linitis”状態 pp.927-936
Published Date 2000/6/25
DOI https://doi.org/10.11477/mf.1403104742
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 The aim of the present study was to describe the prelinitis states in gastric cancer. Therefore, we tested immunohistochemical staining for transforming growth factor-β (TGF-β), its receptor, and mucinous phenotype using immunohistochemistry. In addition, we determined the definition of linitis-type gastric cancer according to Nakamura's reports in which it is thought to be derived from ulcer-negative lesion in the fundic gland area. Its histological character was poorly differentiated adenocarcinoma and signet-ring cell carcinoma (undifferentiated type: por2) with diffuse invasion and dense fibrosis transmurally.

 The ratio of TGF-β to TGF-β type Ⅱ receptor (TGF-β RII) was low in Ⅱc-like type and Ménétrier type advanced gastric cancer in the fundic gland area. This result was similar to that found in linitis-type gastric cancer. Therefore, Ⅱc-like type and Ménétrier type of gastric cancer in the fundic gland area may be considered as one of the pre-linitis states of gastric cancer. The mutation of TGF-βRII had a bearing on the formation of dense fibrosis and varied dedifferentiation in linitis-type gastric cancer.

 We concluded that a close association might exist between evolution of initis-type gastric cancer and TGFβ RII mutation, and dedifferentiation and transforma-tion of mucinous phenotype might also be given rise to as a consequence.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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