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Japanese

Clinicopathological Study of Type 4 Primary Colorectal Carcinomas: Mode of Invasion and Their Histological Type Satoshi Nimura 1 , Kenji Tominaga 1 , Shigeki Sekine 2 , Yukihiro Nakanishi 2 , Tadakazu Shimoda 1 1Clinical Laboratory Division, National Cancer Center Hospital 2Pathology Division, National Cancer Center Research Institute Keyword: 4型大腸癌 , びまん浸潤型大腸癌 , 粘液癌 , 印環細胞癌 , linitis plastica型癌 pp.137-151
Published Date 2002/2/25
DOI https://doi.org/10.11477/mf.1403103423
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 Twenty-four lesions of diffusely infiltrating (type 4) primary colorectal carcinomas from 24 patients without preoperative treatment were studied histopathologically to analyze differences and similarities between the three modes of carcinoma-invasion. The type 4 primary colorectal carcinomas were collected from 1962 through 2000 and were classified as follows: 9 carcinomas of linitis plastica type, 8 carcinomas of lymphangiosis carcinomatosa type, and 7 carcinomas of muconodular type.

 The following conclusions were obtained.

 (1) Type 4 primary colorectal carcinomas were very rare.

 (2) Most of the patients with type 4 primary colorectal carcinomas were found at a late stage of the disease (e.g., directly invading other organs, peritoneal dissemination, and distant metastsis).

 (3) Type 4 primary colorectal carcinomas infiltrated laterally and vertically irrespective of their mode of infiltration. The colorectal wall in type 4 primary carcinomas was markedly thickened along the long segment and its lumen was stenotic.

 (4) Histologically, carcinomas of linitis plastica type showed the morphological features of poorly differentiated adenocarcinoma and/or signet-ring cell carcinoma. Carcinomas of lymphangiosis carcinomatosa type consisted of differentiated adenocarcinoma, while carcinomas of muconodular type consited of differentiated carcinoma and/or signet-ring cell carcinoma.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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