Long-term Follow-up of the Patients with Ulcerative Colitis Masahiro Tada 1 , Masako Okamura 1 , Hirotomo Ootsuka 1 , Seiji Shimizu 1 1The Second Department of Internal Medicine, Kyoto Red Cross Hospital Keyword: 潰瘍性大腸炎 , 長期経過 pp.495-504
Published Date 1991/5/25
DOI https://doi.org/10.11477/mf.1403102530
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 Follow-up study was conducted regarding the morphological changes of the large intestine among 174 patients with ulcerative colitis.Follow-up period was short for 72, medium for 66 and long for 36 patients.

 Among the patients with proctitis or left-sided colitis at the onset, oral extension of the disease process was observed in 8.6% of the short-period group,12.1% in medium-period group and 16.7% in long-period group;the extent of the disease was already determined at the onset in most of the cases.In case of recurrence, the main site of involvement was the sigmoid or more proximal colon in 41.7%.The assessment of the disease activity is in fact complicated, and sometimes difficult by routine colonoscopy.

 Of the morphological changes observed during the follow-up period, shortening and narrowing of the intestine were evaluated.These changes were mild to moderate in all the patients.The sigmoid and transverse colon had the most pronounced change and the rectum slight.While the degree of deformity due to shortening tended to progress with the lapse of time, the degree of narrowing remained relatively unchanged.Endoscopic appearance of the colorectal mucosa in the quiescent phase was related to extent of the disease involvement at the onset, the severity of inflammation and the duration of the active phase.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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