Long-term Outcome of ESD for Early Gastric Cancer Chika Kusano 1 , Takuji Gotoda 1 , Motoki Iwasaki 2 , Hiroyuki Ono 3 , Ichiro Oda 1 , Takeshi Nakajima 1 , Chizu Yokoi 1 , Tsuyoshi Kikuchi 1 , Shinsuke Kiriyama 1 , Shose Fukunaga 1 , Taku Sakamoto 1 , Yosuke Horita 1 , Hitoshi Nishitani 1 , Risa Kikuyama 1 , Shin Namiki 1 , Tadakazu Shimoda 4 1Endoscopy Division, National Cancer Center Hospital, Tokyo 2Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 3Endoscopy and GI Oncology Division, Shizuoka Cancer Center, Shizuoka, Japan 4Clinical Laboratory Division, National Cancer Center Hospital, Tokyo Keyword: 早期胃癌 , ESD , 適応拡大 , 胃癌治療ガイドライン , 長期予後 pp.74-80
Published Date 2008/1/25
DOI https://doi.org/10.11477/mf.1403101260
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 With the development of new endoscopic resection techniques such as endoscopic submucosal dissection (ESD), removal of large early gastric cancer (EGC) lesions has become possible. To clarify the long-term outcome of this treatment, 2,335 lesions in a consecutive 1,955 EGC patients were enrolled. They had been treated with endoscopic resection from January, 1999 to December, 2005, at the National Cancer Center Hospital. Clinical outcome of all patients was able to be followed.

 In the histological assessment, the curative resection rate was 78% and the non-curative resection rate was 22%. In the curative resection group among patients who had single lesions, the curative resection rate according to the guide line was 49% and the curative resection rate according to the expanded criteria was 51%. The rate of patients who underwent additional surgery among the non-curative group was 53%. Among the overall 5-year-survival-rate group the curative resection group according to the guideline, the curative resection group according to expanded criteria, and the non-curative resection group with additional surgery, there were not significant differences. Concerning the hazard ratio, the same results were recognized.

 In our study, endoscopic resection especially ESD, using expanded criteria, showed an excellent long-term outcome.

Copyright © 2008, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院