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Japanese

Cytapheresis Therapy for Crohn's Disease―Evaluation by Clinical Features and Intestinal Images Toshiyuki Matsui 1 , Taku Nishimura 1 , Takehiko Seki 1 1Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka Keyword: Crohn病 , 白血球系細胞除去療法 , 大腸・小腸病変 pp.200-215
Published Date 2004/2/25
DOI https://doi.org/10.11477/mf.1403100431
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 Background and Aim : Cytapheresis (CAP) has been successfully used to treat patients with intractable ulcerative colitis (UC). The aim of this study is to evaluate the efficacy of CAP in patients with Crohn's disease (CD), who are resistant to conventional therapies. Subjects and Methods : The subject of this study was11CAP sessions performed in9active CD patients who were refractory to conventional therapies such as nutrition therapy and drug therapies. CAP therapy was performed once a week with concomitant nutritional therapy or drug therapy and, totally, 5 to 7 CAP sessions were carried out before evaluation was attempted. The efficacy was evaluated by changes in clinical features using CDAI, changes in complications and also endoscopic and/or radiographic changes of intestinal lesions. Results : ① Clinical features including CDAI ameliorated in 7 sessions with5patients (63.6%) and 11sessions with 9patients. However, in 4 sessions (4 patients) clinical features did not improve (36.4%). ② Intestinal images ameliorated in6sessions (66.7%) with 4 patients. This means that 4 patients treated in only4sessions did not show improvement in clinical features and in intestinal images. With reference to disease type, colitis-type showed higher response (85.7%) than ileitis-type did (25.0%). Conclusion : CAP therapy was effective in refractory patients and the clinical effectivity rate was 63.6% (7 sessions/11 sessions). Because CAP is a simple and safe maneuver, this therapy is recommended for colitis patients who are refractory to conventional treatment such as nutritional therapy.

 1) Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan


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