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Japanese

Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome pp.914-915
Published Date 1992/10/1
DOI https://doi.org/10.11477/mf.1543901297
  • Abstract

 Nephrotic patients with persistent proteinuria also have various lipid abnormalities that may promote atherosclerosis and more rapid progression of renal disease. We aimed to find out whether dietary manipulation can correct the hyperlipidaemia found in these patients.

 After a baseline control period of 8 weeks on their usual diets, 20 untreated patients with chronic glomerular diseases, stable long-lasting severe proteinuria (5.9 [SD 3.4] g/24 h) and hyperlipidaemia (mean serum cholesterol 8.69 [3.34] mmol/l) ate a vegetarian soy diet for 8 weeks. The diet was low in fat (28% of total calories) andprotein (0.71 [0.36] g/kg ideal body weight daily), cholesterol free,and rich in monounsaturated and polyunsaturated fatty acids (polyunsaturated/saturated ratio 2.5) and in fibre (40 g/day). After the dietperiod the patients resumed their usual diets for 8 weeks (washoutperiod). During the soy-diet period there were significant falls inserum cholesterol (total, lew-density lipoprotein, and high densitylipoprotein) and apolipoproteins A and B, but serum triglycerideconcentrations did not change. Urinary protein excretion fellsignificantly. The concentrations of all lipid fractions and the amountof proteinuria tended to return towards baseline values during thewashout period.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1375 印刷版ISSN 0301-2611 医学書院

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