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Japanese encephalitis Akihiko Maeda 1 , Hiroshi Wakiguchi 1 1Department of Pediatrics, Kochi Medical School Keyword: 日本脳炎 , 日本脳炎ウイルス , 定期接種 , 日本脳炎ワクチン pp.1306-1312
Published Date 2010/10/30
DOI https://doi.org/10.11477/mf.1542102438
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Japanese encephalitis (JE) was common in Japan in 1960's. Universal immunization has dramatically suppressed the number of JE cases to less than 10 per year. The regular national surveillance shows that the seropositivity of JE virus in pigs that are the reservoirs for the virus remains high in Japan, especially in southern area. Since JE virus is thus prevalent in Japan, the universal immunization against JE virus should be continued in Japan. In 2005, a severe patient who presented with acute disseminated encephaolo-myelitis occurred after receiving the 4th dose of the former mouse brain-derived JEV vaccine, and the rate of vaccinees decreased from 80% to 5%. As JE virus-susceptible children are thereafter increasing, the surveillance of JE patients is now extremely important. A new JE vaccine derived from the cell culture virus has been approved to be used as immunization program and universal immunization program has been restarted since April, 2005. A catch up immunization for the children who missed JE vaccination these five years is expected to be started promptly.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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