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Efficacy of Oral Alendronate in the Treatment of SAPHO Syndrome. Case Report Toshihisa Osanai 1 , Takashi Tsuchiya 1 , Masato Sugawara 1 1Department of Orthopaedic Surgery, Yamagata University School of Medicine Keyword: SAPHO syndrome , SAPHO症候群 , bisphosphonate , ビスホスフォネート , bone metabolic marker , 骨代謝マーカー pp.1147-1151
Published Date 2007/11/25
DOI https://doi.org/10.11477/mf.1408101176
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 Introduction. In other countries bisphosphonates (BPs) have recently been used intravenously to treat SAPHO syndrome, but in Japan intravenous administration of BPs is usually restricted to cancer patients. We report a case of SAPHO syndrome successfully treated by oral administration of a BP.

 Case. A 50-year-old woman with a history of palmoplantar pustulosis complained of pain in the left thigh. A plain radiograph revealed cortical hyperostosis and focal osteolytic changes in the proximal femur, and a diagnosis of aseptic osteomyelitis was made by incisional biopsy. Oral alendronate (5mg/day) was started, and 3 weeks later the severe pain was relieved. Oral alendronate was continued for more than 1 year, and prominent sclerotic changes were observed in the bone lesion. The patient's increased urinary excretion of NTX decreased dramatically after the oral alendronate therapy.

 Conclusion. Oral BPs may be an effective treatment for SAPHO syndrome in patients with increased levels of bone resorption markers.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院

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