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Seishin Igaku Volume 32, Issue 7 （July 1990）

精神医学 32巻7号（1990年7月発行）

Japanese English

研究と報告

内因性うつ病患者の局所脳血流分布について—Xe-133吸入法SPECTを用いての検討 Regional Cerebral Blood Flow in Endogenous Depression: Using SPECT by Xe-133 inhalation method 佐川勝男 ¹ , 森信繁 ¹ , 川勝忍 ¹ , 生地新 ¹ , 渋谷磯夫 ¹ , 東谷慶昭 ¹ , 灘岡壽英 ¹ , 十束支朗 ¹ , 矢崎光保 ² , 駒谷昭夫 ³ Katsuo Sagawa ¹ , Shigeru Morinobu ¹ , Shinobu Kawakatsu ¹ , Arata Oiji ¹ , Isoo Shibuya ¹ , Yoshiaki Higashitani ¹ , Toshihide Nadaoka ¹ , Shiro Totsuka ¹ , Mitsuyasu Yazaki ² , Akio Komatani ³ ¹山形大学医学部精神神経医学講座 ²総武病院 ³山形大学医学部放射線医学講座 ¹Department of Neuropsychiatry, Yamagata University School of Medicine ²Soubu Hospital ³Department of Radiology, Yamagata University School of Medicine キーワード： Regional cerebral blood flow , Endogenous depression , Rating scale , Laterality , Hypofrontality Keyword: Regional cerebral blood flow , Endogenous depression , Rating scale , Laterality , Hypofrontality pp.751-757

発行日 1990年7月15日 Published Date 1990/7/15

DOI https://doi.org/10.11477/mf.1405902876

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Abstract 文献概要
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　抄録　健常者20名，うつ病患者29名にっいて，Xe-133吸入法により局所脳血流量（rCBF）を測定した（HEADTOME Ⅱ，リング型SPECT）。

　健常者群と双極性うつ病者群では局所脳血流量に有意の差はなかった。単極性うっ病者群では健常者群に比較して全般的な脳血流の低下が認められたが，特に左の側頭頭頂葉領域での血流低下が目立った（p＜0.01）。

　The subjects were twenty-nine depressed patients who met the DSM-Ⅲ rd criteria for bipolar disorder or major depression. The rCBF was determined by the Xe-133 inhalation method (HEADTOME: ring type SPECT).

　There were no significant differences in the rCBF values between the patients with bipolar depression and normal controls. The rCBF values of patients with unipolar depression were significantly lower than those of controls, especially in the left temporoparietal region (p＜0.01).

　There were no significant correlations between scores on Hamilton rating scale for depression (HRSD) and the rCBF values.

　Laterality of the rCBF was not observed in the patients with bipolar depression, but it was seen in both the patients with unipolar depression and the controls. The asymmetry of rCBF values in the temporoparietal region (R＞L) were more noticeable (p＜0.01) in unipolar depression patients than in bipolar depression patients.