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Analysis of Clinical Profiles of Elder Patients with Paroxysmal Atrial Fibrillation and Efficacy of Antiarrhythmic Drugs: Comparison with younger patients Takashi Komatsu 1 , Shin Nakamura 1 , Masao Kimura 1 , Yasushi Tomita 1 , Shingen Oowada 1 , Kunihiko Yomogida 1 , Ken Okumura 2 1The Division of Cardiology, Department of Internal Medicine, Iwate Prefectural Iwai Hospital 2The Second Department of Internal Medicine, Hirosaki University School of Medicine Keyword: 発作性心房細動 , 高齢者 , 停止効果 , 予防効果 , 抗不整脈薬 , paroxysmal atrial fibrillation , elder , antiarrhythmic drugs , termination , prevention pp.1015-1020
Published Date 2001/10/15
DOI https://doi.org/10.11477/mf.1404902367
  • Abstract
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 To assess clinical profiles of high-aged patients with paroxysmal atrial fibrillation (Paf) and termination and long-term prevention effects of aggressive antiarrhythmic drugs, 235 patients (172 men, 63 women, mean age 67±10 years) were enrolled in a retrospective study (mean follow-up period 38.6±29.5 months). Successful termination with drugs was defined as defibrillation after intravenous injection of antiarrhythmic drugs within 30 minutes, and successful prevention of the arrhythmic recurrence was defined as the maintenance of sinus rhythm after aggressive antiarrhythmic treatment. The ratios of female (32.8% vs 18.4%), hypertension (48.2% vs 29.6%) and thromboembolism (23.4% vs 10.2%) in elder patients (65≧years, N=137) weresignificantly higher than those in younger patients (65<years, N=98) (p<0.05). There was no difference between elder and younger patients in the rates of termination of the arrhythmia (48% vs 60%) and prevention of the arrhythmia (88% vs 91%) at 48 months.

 On the other hand, the incidence of side effects of antiarrhythmic treatment in elder patients (9A%) was significantly higher than that in younger patients (2.0%) (p<0.05).

 These results suggest that antiarrhythmic drugs are equally effective in both elder and younger patients although adverse effects may develop more frequently among elder patients.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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