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Japanese

Esophagus-preserving Therapy for Tlb Cancer from the Aspect of Molecular Alterations Soji Ozawa 1 , Yuko Kitagawa 1 , Nobuhiko Okamoto 1 , Yoshimasa Shimizu 1 , Masaki Kitajima 1 1Department of Surgery, School of Medicine, Keio University Keyword: 食道癌 , sm癌 , 遺伝子・分子診断 , リンパ節転移 , 食道温存治療 pp.1299-1303
Published Date 2002/9/25
DOI https://doi.org/10.11477/mf.1403104545
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 It has been reported that metastasis to regional lymph nodes in esophageal cancer is related to amplification of c-erbB, 8q23-qter, and 20q, abnormal expression of p16, loss of 11q22-qter and 13q12-13, elevated levels of argyrophilic nucleolar organizer regions (AgNOR), abnormal expression of vascular endothelial growth factor (VEGF), Fas L, and MTA1, elevated levels of T/N ratio of ornithine decarboxylase (ODC). Endoscopic biopsy is necessary to obtain samples to be analyzed. Because molecular information from biopsy samples is useful but not an absolute indicator, esophagus-preserving therapy for Tlb cancer should be chosen on the basis of conventional image diagnosis methods in conjunction with the new concept of lymphoscintigraphy.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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