Morphometric Analysis of Atypia Grading of Colorectal Villous Tumors Shin-ichi Ban 1 , Kyoichi Nakamura 2 , Yasuo Ohkura 3 , Tatsuya Ishido 4 , Kiyoshi Saitoh 1 1Institute of Basic Medical Sciences, University of Tsukuba 2The First Department of Pathology, School of Medicine, Tokyo Medical and Dental University 3Tokyo Metropolitan Cancer Detection Center 4Tsuchiura-kyoudou Hospital Keyword: 大腸絨毛状腫瘍 , 組織形態計測 , 異型度係数 , 二変量線形判別関数 , 構造異型 pp.1193-1199
Published Date 1991/10/25
DOI https://doi.org/10.11477/mf.1403102673
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 Fifty cases of villous tumors were evaluated regarding atypia grading by means of computer-aided histological morphometry. Two indices (ING and ISA) were defined to quantify cellular and structural atypia of the villous tumors. The ING is a kind of N/C ratio and the ISA represents density of glands.

 The mean value of ING and ISA for villous tumors were 42.5±8.07and88.8±3.97, respectively. The mean value of ING was similar to that for tubular adenomas and the mean value of ISA was greater than that for adenocarcinomas (Table 2). The correlation diagram of ISA and ING showed that the values for villous tumors were distributed in the borderline area between tubular adenomas and adenocarcinomas. The linear discriminant function (F) obtained from the ING and ISA values for tubular adenomas and adenocarcinomas was applied to 106 fields of 50 villous tumors. Seventy percent of them were discriminated as malignant (Fig.3). It was thought that the discriminant function (F) should be shifted to the benignancy side, taking into consideration the index values of definitely malignant villous tumors and large villous tumors (more than 5 cm in size)(Table3). The shifted discriminant function (Fv) was capable of classifying 95% of 106 fields of 50 villous tumors as malignant (Figs.4 and 5).

 Based on these results, villous structures should be regarded as one of the structural atypia of malignant epithelial tumors of the colorectum.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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