Inactivation Process of K-Permeability in Skeletal Muscle Fibres

　In 1941 Cole and Curtis^3） observed in the squid giant axon that depolarization caused a striking decrease in the membrane resistance. Later this phenomenon was confirmed by Hodgkin, Huxley and Katz^9）（1949），and was designated as "delayed rectification." They attributed this decrease in the membrane resistance to an increase in potassium permeability which occurred as the membrane was depolarized. They interpreted part of the cause of repolarization phase of action potential in the squid giant axon by this increase in K permeability.