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Targeting chemo-thermotherapy for malignant gliomas by thermosensitive liposome Kenichi KAKINUMA 1 , Ryuichi TANAKA 1 1Department of Neurosurgery, Brain Research Institute, Nilgata University Keyword: グリオーマ , 熱感受性リポソーム , 化学温熱療法 , drug delivery system pp.431-442
Published Date 1999/6/10
DOI https://doi.org/10.11477/mf.1431901062
  • Abstract
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Thermosensitive liposome is a new drug carrier. They are microscopic vesicles composed of phospholipid bilayers that can contain antitumor drugs. Each phospholipid has each transition temperature. With the combination of an appropriate pair of phospholipid, a single transition temperature can be obtained. Consequently, thermosensi-tive liposomes remain relatively stable in the bloodstream at physiological temperatures and they release the highly concentrated antitumor drugs effectively when reaching their transition temperature.We described herein the effectiveness of targeting chemo-thermotherapy for malignant gliomas using thermosensitive liposome and interstitial radiofrequency hyperthermia. First of all, the authors demonstrated that the combination of thermosensi-tive liposome containing CDDP and hyperthermia focused CDDP to the experimental brain tumor, providing a greater antitumor effect. Our hyperthermic treatment, above 42°C, can treat the entire tumor core of human malignant glioma for direct thermal killing. When heating, the 40°C area extended up to a wide portion, covering the area invaded by tumor cells. Therefore, a more effective thermosensitive liposome was developed for clinical use. It was designed to release Adriamycin (ADR) at 40°C and above. As a result, this new thermosensitive liposome sharply released ADR at a temperature of 40°C as planned, bringing a significantly greater antitumor effect in rat tumor models.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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