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Inter-Organ Metabolic Communication via the Unfolded Stress Response. Miyake Masato 1 , Oyadomari Seiichi 2 1Division of Molecular Biology, Institute for Genome Research/Diabetes Therapeutics and Research Center/Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan. 2Division of Molecular Biology, Institute for Genome Research/Diabetes Therapeutics and Research Center/Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan. pp.1548-1553
Published Date 2018/10/28
DOI https://doi.org/10.20837/42018111548
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 Organs do not independently coordinate their metabolic activity:close communication between different organ systems is essential to regulate metabolism effectively. In recent years, the unfolded protein response(UPR), which is an adaptive mechanism to decrease the amount of unfolded or misfolded proteins in the ER, has been found to regulate metabolic function not only at the cellular level but also at the whole-organism level by way of inter-organ communications. This manuscript will present the most recent findings on the role of the UPR in inter-organ metabolic networks.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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