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Induction Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer Akihiro Miura 1 , Junichi Soh 1 , Kazuhiko Shien 1 , Hiromasa Yamamoto 1 , Shinichi Toyooka 1 1Department of Thoracic Surgery, Okayama University Hospital Keyword: induction chemoradiotherapy , locally advanced non-small-cell lung cancer , treatment result pp.270-277
Published Date 2018/4/1
DOI https://doi.org/10.15106/j_kyobu71_270
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The management of locally advanced non-small cell lung cancer (LA-NSCLC) is still controversial, because of complicated patient status and poor prognosis. The purpose of this study was to evaluate the treatment results for induction chemoradiotherapy (iCRT) followed by surgery for LA-NSCLC. From 1999 to 2016, 157 patients were surgically treated after iCRT in our hospital, and their median follow-up was 43 months. Overall survival (OS) was 66.8%, and relapse-free survival (RFS) was 52.0%.The poor prognostic factor in OS by multivariate analysis was lower-lobe origin, incomplete radiotherapy, reoperation, and RFS was lower-lobe origin. The result of our hospital was feasible compared with definitive CRT. The definitive CRT is mainstream for treatment of LA-NSCLC and adjuvant anti-programmed death ligand 1 antibody will influence the treatment strategy, however there are some patients who can get benefit only by iCRT followed by surgery. iCRT followed by surgery is one of the feasible treatment for LA-NSCLC.


© Nankodo Co., Ltd., 2018

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電子版ISSN 2432-9436 印刷版ISSN 0021-5252 南江堂

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