血清ProGRPが高値を示した非定型肺カルチノイドの1例

Atypical Pulmonary Carcinoid Tumor with Elevated Serum ProGRP；Report of a Case

緩徐な増大傾向を呈す境界明瞭な孤立性肺結節影を認める場合，肺過誤腫などの良性腫瘍との鑑別が困難な場合がある．ProGRPが高値を示し，術前にカルチノイド腫瘍などの神経内分泌腫瘍を疑い手術を行った非定型肺カルチノイドの1例を経験したので報告する．

We report a case of an atypical pulmonary carcinoid with high serum ProGRP. A 78-year-old man was found to have an abnormal shadow by a chest X-ray. Chest computed tomography （CT） revealed a solitary pulmonary nodule in the right middle lobe, which was homogeneous, well demarcated, and round. The level of serum ProGRP was elevated to 104.6 pg/ml （normal＜81 pg/ml）. The nodule was suspected to be a pulmonary carcinoid tumor, and a right middle lobectomy with mediastinal lymph node dissection was performed. Histopathological diagnosis was an atypical pulmonary carcinoid. ProGRP decreased to be normal level 5 month after operation.