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Bioactive metabolites derived from n-3 polyunsaturated fatty acids with anti-inflammatory properties Makoto Arita 1,2 1Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo 2PRESTO, Japan Science and Technology Agency Keyword: ω3系脂肪酸 , 抗炎症作用 , メタボロミクス , 脂質メディエーター pp.165-170
Published Date 2012/2/15
DOI https://doi.org/10.11477/mf.1542102917
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Dietary supplementation of n-3 polyunsaturated fatty acid (PUFAs) including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has been held to be beneficial for human diseases in which inflammation is suspected as a key component in pathogenesis. Also, elevation in n-3 PUFA levels in n-3 desaturase (fat-1) transgenic mice that endogenously biosynthesize n-3 PUFA from n-6 PUFA led to effective protection against inflammation and tissue injury. Several possible mechanisms to explain n-3 PUFA's actions are proposed : preventing conversion of n-6 arachidonic acid to pro-inflammatory eicosanoids, serving as an alternative substrate producing less potent products, or being converted to potent anti-inflammatory mediators (i.e. resolvins and protectins). These metabolites may underlie some of the beneficial actions of n-3 PUFAs in controlling inflammation and related diseases.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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