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Effect of CDP-choline administered intrathecally on disturbance of consciousness Keiji SANO 1 , Shinya MANAKA 1 , Koichi KITAMURA 2 , Mizuo KAGAWA 2 , Kazuo TAKEUCHI 3 , Motohide OGASHIWA 3 , Norio NAKAMURA 4 , Shozo ISHII 5 , Hideyuki HIRAI 6 , Naoya TACHIBANA 7 1Department of Neurosurgery, Faculty of Medicine, University of Tokyo 2Department of Neurosurgery, Tokyo Women's Medical College 3Department of Neurosurgery, Kyorin University, School of Medicine 4Department of Neurosurgery, The Jikei University, School of Medicine 5Department of Neurosurgery, Juntendo University, School of Medicine 6Department of Neurosurgery, Saiseikai Kanagawaken Hospital 7Department of Anesthesiology, Faculty of Medicine, University of Tokyo pp.835-849
Published Date 1977/8/10
DOI https://doi.org/10.11477/mf.1431904792
  • Abstract
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In 126 cases of the patients with prolonged disturbance of consciousness, CDP-choline was administered intravenously in doses of 500mg (58 cases) or 500 mg intravenously together with 150 mg intrathecally (68 cases) and the effectiveness and safety of these types of administration were comparatively studied. Although the effectiveness of the intrathecal administration was confirmed, indication of this types of administration is considered to be limited to special cases in view of the safety in such a type of administration.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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