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Japanese

Mechanisms of bone cancer pain Tomoyuki Kawamata 1 1Department of Anesthesiology, Sapporo Medical University School of Medicine Keyword: TRPV1 , 骨がん , エンドセリン-1 pp.940-941
Published Date 2006/12/10
DOI https://doi.org/10.11477/mf.1431100415
  • Abstract

 Bone cancer pain is difficult to treat and has a strong impact on the quality of life of the cancer patients. Now, we have tried to analyze a mouse model of bone cancer pain. To date, we found two mechanisms of bone cancer pain. One is the down-regulation of μ opioid receptor expression and the up-regulation of CCKB receptor in peripheral nervous system. The other is the involvement of TRPV1. TRPV1 expression was increased in the DRGs in a transcription-dependent fashion, and pharmacological blockade of TRPV1 reduced bone cancer-related pain behaviors. In addition, the activation of TRPV1 is required for pain induced by endothelin-1, which is an important mediator for bone cancer pain. Therefore, TRPV1 activation plays a critical role in the generation of bone cancer pain.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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