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Physiological role of thalamic phospholipase Cβ4mediated by metabotropic glutamate receptor type 1 in inflammatory pain Mariko Miyata 1 1Department of Information Physiology, National Institute for Physiological Sciences Keyword: 炎症性疼痛 , 視床 , ホスホリパーゼCβ4 , PLCβ4 , 代謝型グルタミン酸受容体1型 , mGluR1 pp.941-946
Published Date 2004/12/10
DOI https://doi.org/10.11477/mf.1431100256
  • Abstract
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 Phospholipase C(PLC)β4, one of the four isoforms of PLCβs, is the sole isoform in the mouse ventroposterolateral thalamic nucleus(VPL), which is involved in pain processing. The mouse VPL has been also shown to express a high level of metabotropic glutamate receptor type 1(mGluR1), which stimulates PLCβs through activation of Gαq/11protein. It is therefore expected that thalamic mGluR1-PLCβ4may play a functional role in nociceptive transmission. We found the thalamic mGluR1-PLCβ4 cascade plays a crucial role on the inflammatory pain but not the acute pain by using the knockout mice and/or pharmacological studies. Furthermore, membrane potentials and spike activities are regulated by mGluR1-PLCβ4 cascade in VPL neurons suggesting that thalamic mGluR1-PLCβ4 cascade mediates the inflammatory pain by regulating the response of VPL neurons.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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