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Genetic epidemiology in Alzheimer's disease Katsuya Urakami 1 , Miyako Taniguchi 1 , Kenji Wada 2 , Yosuke Wakutani 2 , Kenji Nakashima 2 1Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University 2Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University Keyword: アルツハイマー病 , 酸化ストレス , 治療 , 遺伝子多型 pp.395-401
Published Date 2005/6/10
DOI https://doi.org/10.11477/mf.1431100056
  • Abstract
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Alzheimer's disease(AD)recently exists 1 per 20 aged over 65 elderly people in Japan. Therefore, we consider AD as a common disease. Since apolipoprotein E(apo E)reported as a genetic risk factor for sporadic AD, many candidate genes have been examined. However, no candidate genes except for apo E did not reach to definite conclusion. Now, oxidative stress has been focused as a pathogenic factor for AD. Donepezil hydrochloride is available in Japan and it is possible to treat AD patients. However, it is very difficult to predict responder and non-responder. Therefore, it is very useful to predict efficacy for this drug using genetic polymorphism. We introduced previously reported genetic polymorphism for AD and also introduced our data about genetic polymorphism related to oxidative stress and acetylcholine. As genetic polymorphism except for apo E has not yet found, it is necessary to identify new candidate gene for AD in the future.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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