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Systemic ganciclovir was effective in 3 cases of cytomegalovirus retinitis Machiko Yano 1 , Akio Hirano 2 , Tsuyoshi Ishida 3 , Kazuyo Ataka 4 , Manabu Mochizuki 4 1Dept of Ophthalmol, Cancer Institute Hosp 2Dept of Chemotherapy, Cancer Institute Hosp 3Dept of Pathol, Cancer Institute Hosp 4Dept of Ophthalmol, Tokyo Univ Branch Hosp pp.789-792
Published Date 1990/6/15
DOI https://doi.org/10.11477/mf.1410908169
  • Abstract
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Cytomegalovirus retinitis developed in 3 patients while under chemotherapy for malignant lymphoma. We treated the patients with intra-venous ganciclovir at the dosis of 5 mg/kg twice daily for 9 to 21 days. The response was prompt and favorable in 3 eyes in which treatment was initiatedduring the early stage of retinitis. The therapeutic effect was negligible in one eye with advanced retinitis and retinal necrosis.

The retinitis remained in regressed state until death in 2 patients. The retinitis recurred in another 17 days after withdrawal of systemic ganciclovir. During treatment with ganciclovir, leucopenia developed in all the 3 cases and thrombocytopenia in 2. Both these side effects were reversible. Sys-temic ganciclovir promises to be the treatment of choice for cytomegalovirus retinitis in its early stage.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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