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Brain and Nerve No to Shinkei Volume 42, Issue 4 （April 1990）

Brain and Nerve 脳と神経 42巻4号（1990年4月発行）

Japanese English

原著

Alzheimer病におけるMagnocellular basal forebrain systemの細胞計測学的検討 MORPHOMETRIC STUDY OF THE MAGNOCELLULAR BASAL FOREBRAIN SYSTEM IN PATIENTS WITH ALZHEIMER'S DISEASE 小林克治 ¹ , 福谷祐賢 ² , 中村一郎 ¹ , 川崎康弘 ¹ , 鈴木道雄 ³ , 山口成良 ¹ , 中西功夫 ⁴ Katsuji Kobayashi ¹ , Yuken Fukutani ² , Ichiro Nakamura ¹ , Yasuhiro Kawasaki ¹ , Michio Suzuki ³ , Nariyoshi Yamaguchi ¹ , Ikuo Nakanishi ⁴ ¹金沢大学医学部神経精神医学教室 ²国立療養所北陸病院神経科精神科 ³高岡市民病院精神神経科 ⁴金沢大学医学部第一病理学教室 ¹Department of Neuropsychiatry School of Medicine, Kanazawa University ²National Sanatorium Hokuriku Hospital ³Takaoka Municipal Hospital ⁴Department of Pathology, School of Medicine, Kanazawa University キーワード： nucleus basalis of Meynert , morphometry , Alzheimer's disease , immunocytochemistry Keyword: nucleus basalis of Meynert , morphometry , Alzheimer's disease , immunocytochemistry pp.345-351

発行日 1990年4月1日 Published Date 1990/4/1

DOI https://doi.org/10.11477/mf.1406900041

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Abstract 文献概要
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　Alzheimer病（AD）におけるMagnocellular basal forebrain system（MBFS）の神経細胞の形態計測学的検討を行った。AChEによる免疫染色を行い，この部位の同定を確実にし，計測はcresylviolet染色標本を用いて行った。3例の対照と3例のADを検索し，MBFS全体で約50％の神経細胞脱落があり，AD症例2では無名質にもNFTが見られた。内側中隔核では神経細胞面積の企範囲にわたり神経細胞脱落がありブローカー斜束核では200μm²以上の神経細胞脱落がありAD症例3では200μm²以下の神経細胞が逆に増加していた。無名質マイネルト基底核では250μm²以上の神経細胞脱落と250μm²以下の小型神経細胞が保たれる傾向があり，無名質マイネルト基底核においては大型の神経細胞が変性脱落を受けやすく，ブローカー斜束核でも類似の傾向がみられた。内側中隔核，ブローカー斜束核では非コリン作動性の神経釧胞も脱落していると考えられADにみられる痴呆，巣症状に関して他のモノアミン系の障害の関与も考えられた。

Morphometric study of neurons within the mag-nocellular basal forebrain system (MBFS) in the three normal controls and three cases with Alz-heimer's disease (AD) was studied. Immunocytoche-mical staining using anti-acetylcholinesterase was performed to identify the measuring areas of the MBFS, and cross sectional areas of all neurons within the MBFS in one preparation was measu-red making use of cresyl violet staining. About 50% of the entire neuronal cells within the MBFS were decreased and case 2 had neurofibrillary tangles in the substantia innominata. In the septal nucleus neuronal cell depopulation was observed through the all range of the neuronal cell size, and in the diagonal band of Broca neuronal cells of which cross sectional areas were more than 200 μm² were preferentially decreased and case 3 had inverse increase of the neurons of which cross sectional areas were less than 200 μm². In the basal nucleus of Meynert in the substantia innominata neurons of which cross sectional areas were more than 250 μm² were markedly decreased and neurons of which cross sectional areas less than 250 μm² were well preserved. The large neurons within the basal nucleus and diagonal band of Broca were more affected in AD. In the septal nucleus and diagonal band it was suspected that non-cholinergic neurons were also decreased and these findings suggested that other series of monoamines also bore a relationship to the de-mentia and neuropsychological symptoms in AD.