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ELECTRON MICROSCOPIC OBSERVATION HETATOCELEULAR CHANGES IN WILSON'S DISEASE Tetsuji SANTA 1 , Hiroshi SHIBASAKI 1 , Tetsuo INOKUCHI 1 1Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu Uuiversity pp.941-946
Published Date 1968/9/1
DOI https://doi.org/10.11477/mf.1406202436
  • Abstract
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Two cases of Wilson disease were reported on the electron microscopic study of liver biopsy speciemens.

One of the main features was an increase in the number of lysosomes These are considered as pro-bable site of accumulation of copper. Other chan-ges were dilatation of the endoplasmic reticulum, intranuclear inclusion body such as glycogen deposit and osmophilic lamellor body, and morphological alteration in some mitochondria.

The number of cytoplasmic tat deposit, the en-largment of space between liver cells and the in-crease of collagen fibers were also found.

These alterations may be considered to be the result of the disturbance in copper metabolism in Wilson's disease.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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