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Japanese

THE EFFECT OF URINARY COPPER EXCRETION OF GLUTATHIONE COMBINED WITH D-PENICILLAMINE IN WILSON'S DISEASE Yasuro MATSUBA 1 , Toru NAKAHACHI 1 , Taku TERAI 1 , Tesuo KOZAKAI 1 1Dept. of Psychiatry, Niigata Univ. School of Medicine pp.187-195
Published Date 1968/2/1
DOI https://doi.org/10.11477/mf.1406202350
  • Abstract
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1) Although a slight increase in urinary copper excretion may be occurred during administration of glutathione the effect of this regimen is difficult to evaluate by a combined administration schedule of both glutathione and D-penicillamine. How-ever, tissue copper is excreted and appears in urine in larger amounts than D-penisillamine.

2) Possible mechanism of glutathion as ceruloplasmin oxydase activity inhibititor is decolorization of purple PPD+ product.

3) I atom of Copper (Cu2+) react with 4 molecules of glutathione in 0.1 N-acetic acid-sodium, ace-tate (pH 5.5) and veronal-Na buffer (pH 7.4)

4) It seems that side effects of D-penisillamine and hepatic symptom of Wilson's disease are improved, dosage of D-penicillamine can be minimized, by glutathione administration (Ca. 300-500 mg ave-rage).


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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