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CLINICO-PATHOLOGIC STUDIES ON DISEASES OF THE NERVOUS SYSTEM : 2. ACASE REPORT ON SPASTIC SPINAL PARALYSIS ASSOCIATED WITH A SORT OF ENCEPHALITIS Mitsumasa Abe 1 1National Chikushi Hospital pp.977-982
Published Date 1961/12/1
DOI https://doi.org/10.11477/mf.1406201162
  • Abstract
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1. A man without familial heredity of diseases of the nervous system developed disturbances of speech and spastic paresis of the right leg when he was 36 years of age. Spastic paresis of the upper and lower extremities got worse from the right leg to the left and then from the right arm to the left. At the time of 40 years the upper and lower extremities revealed complete and par-alysis and the entire body showed marked rigidity like a board. On the other hand, disability of speech, atrophy of tongue, and difficulty of swallowing due to pseudobulbar paralysis became striking. The patient did not respond to the treatment for syphilis and these signs were gradually aggravated. After a clinical course of five years and a half, the patient (41 years and 4 moths old) became very weak and died.

2. On autopsy, symmetric demyelination of the pyramidal tract was seen mainly in the first neuron at the level of the midbrain to the lumbar spinal cord. In the areas of demyelination there was gliosis also present,and fat was poorly deposited in these areas. The second neuron, nerve cells such as nuc-leus hypoglossus and anterior column, were of no remarkable changes.


Copyright © 1961, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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