雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Molecular Mechanism Related to Tumor Site in Colorectal Cancer Yasuyuki Okamoto 1,2 , Byonggu An 3 , Yutaka Kondou 4 1Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 2Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, USA 3Department of Surgery, Ako City Hospital, Ako, Japan 4Division of Molecular Oncology, Aichi Cancer Center Research Institue, Nagoya, Japan Keyword: 大腸癌 , DNAメチル化 , CIMP , MSI , CIN pp.1983-1988
Published Date 2012/12/25
DOI https://doi.org/10.11477/mf.1403113679
  • Abstract
  • Look Inside
  • Reference

 Recent molecular analysis for CRCs(colorectal cancers)have revealed that at least three molecular pathways contribute to tumorigenesis ; MSI(microsatellite instability), CIN(chromosomal instability), and recently characterized epigenetic abnormalities. CRCs with MSI, which is characterized by the presence of frame-shift mutations in microsatellite repeats, tend to occur in the proximal colon and generally associate with good prognosis, while CRCs with CIN is characterized by the presence of aneuploidy and chromosomal alterations, and tend to occur in the distal colon. Another distinct pathway, CIMP(CpG island methylator phenotype), which is characterized by excessive gene methylation, has been considerably studied recently. Further, a series of studies revealed that CIMP could be classified into two subgroups. CIMP1/CIMP-H CRCs occur in the proximal colon, have BRAF mutation, and are related to good prognosis, while CIMP2/CIMP-low CRCs frequently have K-ras mutation and show poor prognosis. These molecular mechanisms indicate that CRCs are no longer viewed as a single disease : CRCs in each pathway show distinct clinicopathological features including tumor location, with important implications for prevention, screening, and therapy.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有