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Stomach and Intestine(Tokyo) Volume 15, Issue 10 （October 1980）

胃と腸 15巻10号（1980年10月発行）

Japanese English

今月の主題症例・研究特集

研究

大腸腺腫症を伴わない胃底腺ポリポージス Fundic Gland Polyposis not Associated with Adenomatosis of the Colon 飯田三雄 ¹ , 八尾恒良 ^1,2 , 渡辺英伸 ^3,4 , 冬野誠助 ⁵ , 尾前照雄 ¹ M. Iida ¹ , T. Yao ^1,2 , H. Watanabe ^3,4 , S. Fuyuno ⁵ , T. Omae ¹ ¹九州大学医学部第2内科 ²現福岡大第1内科 ³九州大学医学部第2病理 ⁴現新潟大第1病理 ⁵福岡市医師会病院 ¹The Second Department of Internal Medicine, Faculty of Medicine, Kyushu University ³The Second Department of Pathology, Faculty of Medicine, Kyushu University ⁵Fukuoka City Medical Association Hospital pp.1111-1118

発行日 1980年10月25日 Published Date 1980/10/25

DOI https://doi.org/10.11477/mf.1403112829

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Abstract 文献概要
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　正常胃底腺の過形成と小囊

胞から成る胃底腺ポリポージス（fundic gland polyposis，以下FGPと略す）は家族性大腸腺腫症症候群（familial adenomatosis coli syndrome，以下FACと略す）に特有な胃病変と考えられ，またこのポリープの消褪はFACの大腸切除に関係するものと考えられてきた^1)～4)．しかし最近，FACと関係のない（non-FAC）FGPの報告がみられ^5)～7)，われわれもnon-FACでFGPを伴った9例を経験した．しかもこの症例には経過観察中にFGPが自然消褪したものがあった．

　本稿では，non-FACにおけるFGPを中心に述べ，FACにみられるFGPと比較し，その発生要因についても考察を加えた．

　We have reported previously that fundic gland polyposis consisting of simple hyperplasia of fundic glands seems to be the gastric lesion specific to familial adenomatosis coli syndrome. In this study, nine patients (group A) not associated with adenomatosis of the colon but with fundic gland polyposis were reported, and were compared with twelve patients (group B) associated with both lesions.

　1) Age and sex: The average age was 48.0 years (32 to 65) in group A, and 25.3 years (11 to 41) in group B. Group A included 3 males and 6 females, while group B, 7 males and 5 females. The age of group A was significantly higher than that of group B (p＝0.01).

　2) Characteristics of polyps: Fundic gland polyposis in group A was most commonly distributed in the middle and lower part of the gastric body. These polyps were multiple (2 to 50 in number), measuring up to 8 mm in the greatest dimension, and sessile or subpedunculated with a smooth surface. Only one patient had three pedunculated and relatively large polyps. On the other hand, the number of polyps in group B was larger (over 100) than that of group A. In addition, the polyps in group B were sited either diffusely from the fornix to the lower part of the body or lacally in the fornix. Therefore, we found that it is possible to differentiate group A from group B only through x-ray examinations of the stomach.

　3) Follow up of polyps: Eight patients in group A were followed up by x-ray examination of the stomach and gastro-fiberscopy. In five patients (32 to 55 years, female), multiple polyps disappeared or decreased in number and size in the course of seven months to about three years. The polyps of the remaining three patients (52 to 65 years, male) showed no remarkable change in number and size in the course of a year to about six years.