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Autoradiographic Studies on Polypogenesis of Large Bowel N. Kikkawa 1 , M. Yasutomi 1 1Department of Surgery, Osaka University pp.391-397
Published Date 1975/3/25
DOI https://doi.org/10.11477/mf.1403112254
  • Abstract
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 In our previous report about the exerimentally produced tumors of rats colon, we described that hyperplastic polyp arose from “hyperplastic epithelium focus”, adenomatous polyp from “adenomatous epithelium focus” and cancer arose also de novo. In this report, the histogenesis and morphogenesis of colonic polyp were studied with the 3H-thymidine micro-autoradiography about these 3 types of “atypical epithelium foci”. Compared with the macroscopic tumors, the glandular structures of atypical epithelium foci were simple, and it was possible to determine the germinal zone and the proliferative rate of the mucosal cells.

 The germinal zone of normal epithelium was the lower half of the crypt of Lieberkuhn and its labeling index was 29.1%. In hyperplastic epithelium focus, the zone elongated upward as far as the two thirds of the crypt, but the index was similar (29.0%) to that of normal crypt. On the other hand, adenomatous epithelium focus with atypical cells had not only the upward elongation of the zone, but also the elevation (34.8%) of the labeling index in the lower half of the crypt. And the larger the adenomatous lesions became, the more upward the zone elongated. The germinal zone of the macroscopic tumors such as polyp or cancer could not be decided accurately, but in benign polyp the covering epithelium had no capability to proliferate. In cancerous lesions the distribution of the labeled cells was not uniform and the index was 26.1%.

 These autoradiographic findings of atypical epithelium foci showed two conclusions. First, the initial change of the polypogenesis appeared at the lower portion of the crypt. Secondly, it was reasonable to make a distinction between adenomatous polyp and hyperplastic polyp for the reason of the different genesis of each lesion.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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