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PERORAL BIOPSY OF THE SMALL INTESTINE Tsuyoshi Kihara 1 1The First Dept. of internal Med., Okayama Univ. Medical School pp.453-461
Published Date 1969/4/25
DOI https://doi.org/10.11477/mf.1403111015
  • Abstract
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 The histopathological study of the intestine lags far behind that of other parts of the digestive system, probably because autolytic phenomenon of the intestinal mucosa is invariably observed at necropsy and also because attention of pathologists are more often focussed on such aspects as neoplastic lesions of the intestine as well as its pathology in tuberculosis and typhoid fever, rather than on elucidation of its functional disorders such as absorption defects. Biopsy of the small intestine introduced by M. Shiner has been on that account epochal for the development of pathological study of the intestinal mucosa.

 In this paper is presented a brief description of a history of its development and some comments on its procedures, as well as its clinical application, accidental complications and practical instructions, with priority given to “multi-purpose suction biopsy tube” (Brandborg, L. L. and Rubin, C. R.) now being employed by the authors. Various problems are further discussed of studying histological findings of the intestinal mucosa.

 Flattening and edema of the duodenal mucosa with enlargement of lymphatic space therein, as observed by the authors in cases of liver cirrhosis with portal hypertension, are also described, together with chylus stagnation experienced in extreme portal hypertension. The authors are inclined to classify these pathological phenomenons altogether as “enterose”.

 Behavior of the duodenal mucosa is also studied in acute diarrheal diseases as manifested by its inflammatory changes such as disarrangement of its epithelial cells, into which infiltration of polymorphnuclear leucocytes are seen, or disappearance of brush borders of epithelial cells. These findings are observed to vanish within a short space of time.

 Lastly progress by utilizing biopsies of the intestinal mucosa is referred to in clinical as well as basic studies of the small intestine.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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