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Acute Gastric Changes Due to Alcohol Beverages H. Suzuki 1 , M. Tanaka 1 , T. Takemoto 1 1Institute of Gastroenterology, Tokyo Women's Medical College pp.39-45
Published Date 1973/1/25
DOI https://doi.org/10.11477/mf.1403108341
  • Abstract
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 A study has been made of the effects alcoholic intaken on the gastric mucosa. Also have been collected and tabulated 18 cases of erosion or ulcer in the stomach developing within 24 hours after alcoholic intake with chief complaints of hematemesis and epigastric pain. The effect of a single drink on the gastric mucosa has also been studied in 29 cases by endoscopy combined with biopsy both before and after drinking. The relationship between ingestion of alcoholic drink and atrophy of the gastric mucosa has been investigated too. A usual drink often causes acute changes in the stomach. Less frequently, but more severe symptoms may occur with resultant erosive ulcer. The amount of alcoholic intake and the level of alcohol in the blood were both seemingly related with the appearance of acute gastric changes, but no definite proof has been demonstrated. Changes in the tissue as revealed by biopsy included edema, exerosis, dilated capillary vessels, engorgement, accelerated mucus production, increased erosion in the “Leistenspitze”, swollen basal membrane, degeneration of glandular epithelium, inflammatory cellular infiltration, especially with xeudate of neutrophile cells.

Some relationship was seen between alcoholic intake and chronic gastritis. In a group of drinkers the degree and extent of mucosal atrophy were mostly extensive, while in a teetotalist group atrophy was at time slight, but still at present a definite conclusion can not be drawn.

 In order to study the behavior of the gastric mucosa on alcoholic intake, one should first investigate functional attitude of the mucosa toward alcohol, its biochemical aspects, changes to be seen on the cellular level, or even on molecular level, and only then should one retrospectively study the gastric mucosa on the macroscopic as well as on optical microscopic level.


Copyright © 1973, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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