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An Autopsy Case of Gastric Cancer with Multiple Liver Metastases in which the Primary Site Turned out Pathologically Negative after Chemotherapy G. Akaboshi 1 , T. Fukumoto 1 , H. Maeda 1 , T. Iida 1 , M. Nagaoka 2 1Department of Internal Medicine, Kitakyushu Municipal Cancer Center 2Department of Pathology, Kitakyushu Municipal Cancer Center pp.1701-1706
Published Date 1979/12/25
DOI https://doi.org/10.11477/mf.1403107868
  • Abstract
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 A 57 years old woman with stomach cancer (Borrmann 2) diagnosed inoperable by scintigraphy and angiography for the presence of multiple liver metastases was treated successfully by MFC chemotherapy and local arterial infusion (MMC 10~30mg, given 3 times) followed by maintenance therapy of FT 207 p.o., 800~1200mg per day. An autopsy 16 months after diagnosns showed no cancer in the stomach (the primary lesion) even by serial tissue sections, only showing the presence of fragmentarily scattered muscle fibers at the primary site. Fiberscopic biopsy on July 31, 1978, revealed a well-differentiated tubullar adenocarcinoma. Disappearance of the primary cancer of the stomach by chemotherapy is not reported so far in autopsy cases to our knowledge. Concerning with this, the following factors are considered important. Firstly, the stomach cancer was cytologically a well-differentiated tubullar adenocarcinoma of Borrmann 2. Secondly FT 207 had been given for a long time (a total amount of 243g), and lastly local arterial infusion was done three times in the course. This case strongly suggests the difference of the sensitivity to the antitumor drugs between the primary and the metastatic cancers.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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