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Japanese

Follow-up Studies of Morphological Changes in N-methyl-N'-nitro-N-nitrosoguanidine Carcinogenesis in Stomach of Dogs. (Ⅱ): Early changes leading to development of a depressed-type stomach carcinoma T. Saito 1 , O. Sasaki 1 , R. Tamada 1 , H. Tomoda 2 , M. Furusawa 2 , K. Inokuchi 1 12nd Department of Surgery, Faculty of Medicine, University of Kyushu 2National Kyushu Cancer Center Hospital pp.605-613
Published Date 1976/5/25
DOI https://doi.org/10.11477/mf.1403107237
  • Abstract
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 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was administered to 15 dogs and stomach carcinogenesis was followed by endoscopy and biopsy for 216 weeks. Early changes leading to development of a stomach carcinoma and also early states of carcinoma of a dog, called No. 3, are described here in detail. There were slightly reddened mucosa surrounded with fading at the angle of the stomach 23 weeks after the beginning of administration of MNNG. Thereafter, numerous irregular-shaped reddened spots of pin-point to dime size were observed in the nearly entire mucosa and eroded changes appeared in the mucosa of the angle at 35 weeks. The erosion turned into an ulcer in the angle and the reddened spots were localized to the antral portion at 44 weeks. Biopsy revealed undifferentiated regenerating epithelia, atypical glands and intestinal metaplasia-like glands at the edge and base of the erosion and the ulcer. After the termination of administration of MNNG at the 45th week, the ulcer at the angle was rapidly repaired. Differentiated regenerating epithelia were detected at the healed ulcer. A new depressed lesion appeared in the healed mucosa of the posterior wall side of the angle at 76 weeks. It changed into a demarcated shallow depression like IIc which contained atypical glands by 94 weeks. The Ⅱc-like lesion became a slightly depressed one with irregular marginal elevation, Ⅱc+Ⅱa which proved histologically to be a tubular adenocarcinoma. The early carcinoma showed the phenomenon of so-called malignant cycle between 108 and 110 weeks.


Copyright © 1976, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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