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Experimental Acute Gastric Lesions K. Mizushima 1 , K. Okamura 1 , K. Harada 1 , H. Hayashi 1 , M. Namiki 1 13rd Department of Internal Medicine, Asahikawa Medical College pp.223-232
Published Date 1978/2/25
DOI https://doi.org/10.11477/mf.1403107218
  • Abstract
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 In this paper we present three types of experimentally induced ulcers.

 1. Stress ulcers : We induced stress ulcers in rats, monkeys, and dogs by the restrained water-immersion method and observed their successive gastric mucosal changes with the gastrofiberscope.

 Histologically, these ulcers were hemorrhagic erosions; they appeared two to three hours after stress in the rats and monkeys but 30 hours later in the dogs. Microthrombi were seen at the top of the mucosa and arterioles were cut off at the base of the hemorrhagic erosions. This finding shows a vascular circulatory disturbance. The morphological changes in the adrenal cortex due to stress were a decrease in lipid droplets and an increase in SER. These changes showed the hyperfunction of the organ.

 Bilateral vagotomy, atropine, and tranquilizers significantly reduced the effect of stress on the gastric mucosa. In addition, bilateral adrenolectomy and hexamethonium appeared to prevent gastric mucosal changes.

 Using this data we discussed the hypothetical development of the stress ulcer.

 2. Drug-induced gastric lesions: We tested in the rat stomach the effects of the drug which induce acute gastric lesions in man.

 Aspirin (100 mg/kg) produced a great number of gastric mucosal changes, and the effect of aspirin was strengthened in the presence of predonisolone, but predonisolone alone scarcely affected the rats' gastric mucosa.

 Some anti-diabetic drugs also induced the gastric mucosal changes.

 Glutamine and DV 1006 greatly reduced the incidence of these lesions.

 3. Acute gastric lesions due to vascular circulatory disturbances : We treated four human cases of giant acute gastric ulcers possibly due to vascular circulatory disturbances

 The patients were over 50 years old and showed severe systemic arteriosclerosis.

 In order to induce this type of ulcer in dogs, Gelfoam (10 to 15 mg) was used as embolus and injected into the dogs' left gastric artery. After three days a large acute gastric ulcer resembling that found in the human cases appeared on the anterior wall of the body. Histologically and microangiographically we demonstrated that existing thrombi caused the ulcer. From these results we suggest that if thrombi occur in human arteries and occlude the arterioles, large, acute ulcers may occur.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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