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Japanese

Special Features of Intestinal Metaplasia in Gastric Mucosa and its Relation to Gastic Cancer: By enzyme-histochemical approaches K. Nakahara 1 , H. Tomoda 1 , I. Hayashi 1 1National Kyushu Cancer Center pp.103-112
Published Date 1978/1/25
DOI https://doi.org/10.11477/mf.1403107200
  • Abstract
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 The degree of intestinal metaplasia and its distribution in gastric mucosa were examined by enzymehistochemical approaches as a supplement to histological studies. Leucine aminopeptidase and alkaline phosphatase were used as marker enzymes. The metaplasia which had no LAP activity was not found. Metaplasia was divided into two kinds according to the activity of ALP. The metaplasia which had the activity of ALP was seen in the intermediate zone and the adjacent area to gastroduodenal junction. The metaplasia without the activity of ALP was seen in cardiac and antral portions. The former was morphologically mature with many Paneth cells and well depeloped epithelium. The latter was immature with few Paneth cells and poorly developed epithelium.

 Gastric mucosa containing differentiated tubular adenocarcinoma and papillary carcinoma was associated with more intensive and extensive metaplasia. Furthermore, close correlation between site of lesion and area of metaplasia was confirmed. On the other hand, scanty or no metaplasia was seen in the cases of poorly differentiated carcinoma and signet ring cell carcinoma. No significant relation of these carcinomas to metaplasia was noted. Sixty one cases of early cancer and relatively small advanced cancer without diverse pathological findings were examined for this study. These facts were statistically highly reliable.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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