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Comprehensive Understanding of Clinical, Laboratory, Endoscopic, and Pathologic Findings of Autoimmune Gastritis Based on Its Stage Shuichi Terao 1 , Shiho Suzuki 1 , Akihiko Nishizawa 1 , Yukihiro Imai 2 , Ryoji Kushima 3 1Department of Gastroenterology, Kakogawa Central City Hospital, Kakogawa, Japan 2Department of Diagnostic Pathology, Kakogawa Central City Hospital, Kakogawa, Japan 3Department of Pathology, Shiga University of Medical Science, Otsu, Japan Keyword: 自己免疫性胃炎 , autoimmune gastritis , 病期 , 早期 , 残存胃底腺 , remnant oxyntic mucosa , 胃小区腫脹 , swelling of areae gastricae pp.10-21
Published Date 2024/1/25
DOI https://doi.org/10.11477/mf.1403203444
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 The three stages of AIG(autoimmune gastritis), namely early, middle(active stage), and advanced or end-stage, along with the clinical, laboratory, endoscopic, and pathological findings in each stage have been described in this manuscript. The positivity rate and antibody titer of parietal cell antibodies peak in the middle stage, in contrast, the positivity rate of anti-intrinsic antibodies increases in the advanced or end stages.

 Serum gastrin, PG(pepsinogen)I, and PG I/II ratio exhibited characteristic changes in accordance with the stage of the disease. Iron deficiency anemia tends to be more common in the early to active stages, while pernicious anemia gradually increases toward the advanced and end stage. Note the presence of AIG among the D group in ABC gastric cancer screening test and among refractory to repeated Helicobacter pylori eradication therapy. In endoscopic staging, the main endoscopic finding in the early stage is the swelling of areae gastricae, which reflects early to advanced florid stages of pathohistological staging. In the middle(active)stage, the remnant oxyntic mucosa provides endoscopic assessment of progression of AIG.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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